Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[A single E726Q mutation in the membrane proximal α-helix of integrin β3 subunit induces membrane blebbing by disrupting the membrane-actin cortex interaction].

Zhongguo shi yan xue ye xue za zhi - 1 Dec 2011

Kong Yong-Kui, Zhang Yue, Lin Ming-Hui, Xi Xiao-Dong

Abstract excerpt

The membrane proximal α helix of integrin β subunit cytoplasmic tails plays an important functional role by interacting with various intracellular proteins, namely talin, α-actinin or skelemin. This study was designed to investigate the functional role of 5 highly conserved charged amino acids (R(724), K(725), E(726), E(731), E(733)) within this α helix by site-directed mutagenesis. The result showed that CHO...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Surface Extensions
Share to CHO Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cricetinae

Share to Cricetulus

Share to Heterocyclic Compounds, 4 or More Rings

Share to Integrin beta3

Share to Mutagenesis, Site-Directed

Share to Protein Structure, Tertiary

Source

Identifiers

PMID: 22169302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[A single E726Q mutation in the membrane proximal α-helix of integrin β3 subunit induces membrane blebbing by disrupting the membrane-actin cortex interaction].PMID 22169302Read ↗

Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations.Semantic proximity Read ↗

Basic amino-acid side chains regulate transmembrane integrin signalling.Semantic proximity Read ↗

Integrin β3E726 Regulates the Switch Between Platelet Spreading and Clot Retraction by Interfering Gα13/RhoA Pathway.Semantic proximity Read ↗

The dual structural roles of the membrane distal region of the α-integrin cytoplasmic tail during integrin inside-out activation.Semantic proximity Read ↗

Structural basis of integrin activation by talin.Semantic proximity Read ↗

Breaking the Integrin HingeSemantic proximity Read ↗

A naturally occurring mutation near the C terminus of the beta-propeller of alpha(IIb) impair the transport of alpha(IIb)beta3 complexes from the endoplasmic reticulum to the Golgi apparatus.Semantic proximity Read ↗

Membrane-proximal {alpha}/{beta} stalk interactions differentially regulate integrin activation.Semantic proximity Read ↗

Natural and artificial mutations in αIIb integrin lead to a structural deformation of a calcium-binding site.Semantic proximity Read ↗

Critical residues for ligand binding in blade 2 of the propeller domain of the integrin alphaIIb subunit.Semantic proximity Read ↗

A pivotal role for a conserved bulky residue at the α1-helix of the αI integrin domain in ligand binding.Semantic proximity Read ↗

Talin binding to integrin beta tails: a final common step in integrin activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.