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Article

Polymorphisms in drug transporter genes (ABCB1, SLCO1B1 and ABCC2) and hepatitis induced by antituberculosis drugs.

Tuberculosis (Edinburgh, Scotland) - 1 Jan 2012

Kim Sang-Hoon, Kim Sang-Heon, Lee Jae-Hyung, Lee Byoung-Hoon, Kim Youn-Seup, Park Jae-Seuk, Jee Young-Koo

Abstract excerpt

Unusual drug accumulation is a common mechanism underlying serious drug-induced liver injury. Polymorphisms in three drug transporter genes (ABCB1, SLCO1B1 and ABCC2) may be risk markers for hepatitis induced by the unusual accumulation of anti-tuberculosis drugs (ATDs). We therefore investigated whether polymorphisms and haplotypes of these genes are associated with ATD-induced hepatitis by comparing the...

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Source

Identifiers

PMID: 22178260
DOI: 10.1016/j.tube.2011.09.007

Genes

ABCB1
ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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