Article
Association of UGT2B7 polymorphisms with risk of induced liver injury by anti-tuberculosis drugs in Chinese Han.
International journal of immunopathology and pharmacology - 1 Dec 2017
Chen Guo, Wu Shou-Quan, Feng Mei, Wang Yu, Wu Jing-Can, Ji Gui-Yi, Zhang Miao-Miao, Liu Qian-Qian, He Jian-Qing
Abstract excerpt
Anti-tuberculosis drug-induced liver injury (ATLI) is common during the treatment of tuberculosis (TB). As an important enzyme in the metabolism of many drugs, UGT2B7 (uridine diphosphate glucuronyl transferase 2B7) was associated with drug-induced liver disorder. This study investigated the association between the polymorphisms of UGT2B7 and ATLI in Chinese Han. Totally, 280 newly diagnosed TB patients had been...
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