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Association of polymorphisms in drug transporter genes (SLCO1B1 and SLC10A1) and anti-tuberculosis drug-induced hepatotoxicity in a Chinese cohort.

Tuberculosis (Edinburgh, Scotland) - 1 Jan 2015

Chen Ru, Wang Jing, Tang Shaowen, Zhang Yuan, Lv Xiaozhen, Wu Shanshan, Xia Yinyin, Deng Peiyuan, Ma Yu, Tu Dehua, Chen Dafang, Zhan Siyan

Abstract excerpt

This study investigated the association between genetic variants in two hepatic uptake transporter genes (SLCO1B1 and SLC10A1) and the risk of anti-tuberculosis drug-induced hepatotoxicity (ATDH) in a Chinese cohort. The frequencies and distributions of single nucleotide polymorphisms (SNPs) and haplotypes of these genes were compared among 89 incident ATDH cases and 356 matched ATDH-free controls using a...

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Identifiers

PMID: 25498879
DOI: 10.1016/j.tube.2014.11.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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