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HDAC genes play distinct and redundant roles in Cryptococcus neoformans virulence

26 Mar 2018

Abstract excerpt

The human fungal pathogen Cryptococcus neoformans undergoes many phenotypic changes to promote its survival in specific ecological niches and inside the host. To explore the role of chromatin remodeling on the expression of virulence-related traits, we identified and deleted seven genes encoding predicted class I/II histone deacetylases (HDACs) in the C. neoformans genome. These studies demonstrated that...

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PMID: 29581526
DOI: 10.1038/s41598-018-21965-y

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