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Article

Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans.

Eukaryotic cell - 1 Jul 2006

Cramer Kari L, Gerrald Quincy D, Nichols Connie B, Price Michael S, Alspaugh J Andrew

Abstract excerpt

The Cryptococcus neoformans NRG1 gene was identified using gene microarrays to define putative transcription factor genes regulated by the cyclic AMP (cAMP) signal transduction pathway. Disruption of NRG1 results in delayed capsule formation and mating, two phenotypes that are directly controlled by cAMP signaling. Putative targets of the Nrg1 transcription factor were identified using a second genome microarray...

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Source

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Identifiers

PMID: 16835458
DOI: 10.1128/EC.00145-06
PMCID: PMC1489281

Genes

NRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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