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Histone acetyltransferase Gcn5-mediated histone H3 acetylation facilitates cryptococcal morphogenesis and sexual reproduction

18 Oct 2023

Abstract excerpt

ABSTRACT Sexual reproduction is the primary driving force behind eukaryotic environmental adaptation and evolution. In the human fungal pathogen Cryptococcus neoformans , sexual reproduction plays a critical role in the emergence of highly virulent strains and drug-resistant variants. The sexual life cycle of C. neoformans commences with the yeast-hyphae transition in response to mating stimulation, followed by...

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PMID: 37850793
DOI: 10.1128/msphere.00299-23

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