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Article

Deficiency of cardiolipin synthase causes abnormal mitochondrial function and morphology in germ cells of Caenorhabditis elegans.

The Journal of biological chemistry - 10 Feb 2012

Sakamoto Taro, Inoue Takao, Otomo Yukae, Yokomori Nagaharu, Ohno Motoki, Arai Hiroyuki, Nakagawa Yasuhito

Abstract excerpt

Cardiolipin (CL) is a major membrane phospholipid specifically localized in mitochondria. At the cellular level, CL has been shown to have a role in mitochondrial energy production, mitochondrial membrane dynamics, and the triggering of apoptosis. However, the in vivo role of CL in multicellular organisms is largely unknown. In this study, by analyzing deletion mutants of a CL synthase gene (crls-1) in...

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Identifiers

PMID: 22174409
DOI: 10.1074/jbc.M111.314823
PMCID: PMC3281661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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