Article
Loss of mitochondrial DNA in the yeast cardiolipin synthase crd1 mutant leads to up-regulation of the protein kinase Swe1p that regulates the G2/M transition.
The Journal of biological chemistry - 2 Apr 2010
Chen Shuliang, Liu Dongmei, Finley Russell L, Greenberg Miriam L
Abstract excerpt
The anionic phospholipid cardiolipin and its precursor phosphatidylglycerol are synthesized and localized in the mitochondrial inner membrane of eukaryotes. They are required for structural integrity and optimal activities of a large number of mitochondrial proteins and complexes. Previous studie...
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