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Article

Phospholipid scramblase 3 controls mitochondrial structure, function, and apoptotic response.

Molecular cancer research : MCR - 1 Oct 2003

Liu Jihua, Dai Qiang, Chen Jun, Durrant David, Freeman Angela, Liu Tong, Grossman Douglas, Lee Ray M

Abstract excerpt

Phospholipid scramblase 3 (PLS3) is a newly recognized member of a family of proteins responsible for phospholipid translocation between two lipid compartments. To study PLS3 function in mitochondria, we disrupted its conserved calcium-binding motif yielding an inactive mutant PLS3(F258V). Cells transfected with PLS3(F258V) exhibited reduced proliferative capacity. Mitochondrial analysis revealed that...

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PMID: 14573790

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PLS3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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