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Article

Investigation of Indigoidine Synthetase Reveals a Conserved Active-Site Base Residue of Nonribosomal Peptide Synthetase Oxidases.

Journal of the American Chemical Society - 24 Jun 2020

Pang Bo, Chen Yan, Gan Fei, Yan Chunsheng, Jin Liyuan, Gin Jennifer W, Petzold Christopher J, Keasling Jay D

Abstract excerpt

Nonribosomal peptide synthetase (NRPS) oxidase (Ox) domains oxidize protein-bound intermediates to install crucial structural motifs in bioactive natural products. The mechanism of this domain remains elusive. Here, by studying indigoidine synthetase, a single-module NRPS involved in the biosynthesis of indigoidine and several other bacterial secondary metabolites, we demonstrate that its Ox domain utilizes an...

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PMID: 32510939
DOI: 10.1021/jacs.0c04328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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