Article
Deficiency of NOX1/nicotinamide adenine dinucleotide phosphate, reduced form oxidase leads to pulmonary vascular remodeling.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2014
Iwata Kazumi, Ikami Kanako, Matsuno Kuniharu, Yamashita Toshiharu, Shiba Dai, Ibi Masakazu, Matsumoto Misaki, Katsuyama Masato, Cui Wenhao, Zhang Jia, Zhu Kai, Takei Norio, Kokai Yasuo, Ohneda Osamu, Yokoyama Takahiko, Yabe-Nishimura Chihiro
Abstract excerpt
OBJECTIVE: Involvement of reactive oxygen species derived from nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase has been documented in the development of hypoxia-induced model of pulmonary arterial hypertension (PAH). Because the PAH-like phenotype was demonstrated in mice deficient in Nox1 gene (Nox1(-/Y)) raised under normoxia, the aim of this study was to clarify how the lack of...
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