Article
Cerebrospinal fluid amyloid β and tau in LRRK2 mutation carriers.
Neurology - 3 Jan 2012
Aasly J O, Shi M, Sossi V, Stewart T, Johansen K K, Wszolek Z K, Uitti R J, Hasegawa K, Yokoyama T, Zabetian C P, Kim H M, Leverenz J B, Ginghina C, Armaly J, Edwards K L, Snapinn K W, Stoessl A J, Zhang J
Abstract excerpt
OBJECTIVE: The goal of the current investigation was to examine a cohort of symptomatic and asymptomatic LRRK2 mutation carriers, in order to address whether the reported alterations in amyloid β (Aβ) and tau species in the CSF of patients with sporadic Parkinson disease (PD) are a part of PD pathogenesis, the aging process, or a comorbid disease in patients with PD, and to explore the possibility of Aβ and tau...
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