Article
CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson's disease: a study in LRRK2 mutation carriers.
Translational neurodegeneration - 6 May 2020
Majbour Nour K, Aasly Jan O, Hustad Eldbjørg, Thomas Mercy A, Vaikath Nishant N, Elkum Naser, van de Berg Wilma D J, Tokuda Takahiko, Mollenhauer Brit, Berendse Henk W, El-Agnaf Omar M A
Abstract excerpt
BACKGROUND: Asymptomatic carriers of leucine-rich repeat kinase 2 (LRRK2) gene mutations constitute an ideal population for discovering prodromal biomarkers of Parkinson's disease (PD). In this study, we aim to identify CSF candidate risk biomarkers of PD in individuals with LRRK2 mutation carriers. METHODS: We measured the levels of CSF total- (t-), oligomeric (o-) and phosphorylated S129 (pS129-) α-syn,...
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