Article
Cerebrospinal fluid biomarkers in Progranulin mutations carriers.
Journal of Alzheimer's disease : JAD - 1 Jan 2011
Carecchio Miryam, Fenoglio Chiara, Cortini Francesca, Comi Cristoforo, Benussi Luisa, Ghidoni Roberta, Borroni Barbara, De Riz Milena, Serpente Maria, Cantoni Claudia, Franceschi Massimo, Albertini Valentina, Monaco Francesco, Rainero Innocenzo, Binetti Giuliano, Padovani Alessandro, Bresolin Nereo, Scarpini Elio, Galimberti Daniela
Abstract excerpt
Cerebrospinal fluid (CSF) biomarkers (Aβ₁₋₄₂, total tau, P-181 tau) are currently used to support a clinical diagnosis of Alzheimer's disease (AD). The CSF profile in frontotemporal lobar degeneration (FTLD) caused by Progranulin (GRN) mutation is unknown. We assessed CSF biomarkers in 145 AD, 140 FTLD (20 GRN positive, 120 GRN negative) patients, and 38 controls. Taking into account the reference values used in...
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