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Integrin β3E726 Regulates the Switch Between Platelet Spreading and Clot Retraction by Interfering Gα13/RhoA Pathway.

Thrombosis and haemostasis - 1 May 2026

Peng Jie, Liu Yichen, Zhu Yilin, Xin Honglei, Wang Yun, Xiao Bing, Li Tiantian, Huang Rong, Liu Jing'an, Shao Ruonan, Li Zijian, Wu Jiao, Yan Han, Di Yongqiu, Gan Zijie, Ma Yifei, Mao Jianhua, Chen Shuai, Huang Jiansong, Fang Chao, Xi Xiaodong, Shi Xiaofeng

Abstract excerpt

Platelet spreading and clot retraction, albeit both mediated by integrin outside-in signaling, lead to platelet shape changes in two opposite directions. The mechanisms by which these processes are regulated are not fully understood. Our previous study found that E726Q mutation in β3 integrin caused impaired spreading in Chinese hamster ovary (CHO) cells on immobilized fibrinogen.The current study further...

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PMID: 40719153
DOI: 10.1055/a-2664-7955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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