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Article

Critical residues for ligand binding in blade 2 of the propeller domain of the integrin alphaIIb subunit.

Thrombosis and haemostasis - 1 Jan 2004

Tamura Tatsushiro, Hato Takaaki, Yamanouchi Jun, Fujita Shigeru

Abstract excerpt

Ligand binding to integrin alphaIIbbeta3 is a key event of thrombus formation. The propeller domain of the alphaIIb subunit has been implicated in ligand binding. Recently, the ligand binding site of the alphaV propeller was determined by crystal structure analysis. However, the structural basis of ligand recognition by the alphaIIb propeller remains to be determined. In this study, we conducted site-directed...

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Identifiers

PMID: 14691576
DOI: 10.1160/TH03-06-0392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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