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Near completely reversing the γ- to β-globin switch by enhancer release, retargeting and reinforcing

2026-02-01

Abstract excerpt

The γ- to β-globin switch is intricately regulated during human ontogeny, and this process is manipulated for therapeutic approaches to treat β-hemoglobinopathies by activating γ-globin expression. Several genetic strategies to reactivate HbF have partially reversed the γ- to β-globin switch and ameliorated the clinical symptoms of β-hemoglobinopathies. However, whether the γ- to β-globin switch can be completely...

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Literature Corpus work
9efa643d-d933-5041-ab76-5bdbc571eb08
DOI
10.64898/2026.01.30.702713
Open publication

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Near completely reversing the γ- to β-globin switch by enhancer release, retargeting and reinforcingDOI 10.64898/2026.01.30.702713
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