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Article

The 14q22.2 colorectal cancer variant rs4444235 shows cis-acting regulation of BMP4.

Oncogene - 16 Aug 2012

Lubbe S J, Pittman A M, Olver B, Lloyd A, Vijayakrishnan J, Naranjo S, Dobbins S, Broderick P, Gómez-Skarmeta J L, Houlston R S

Abstract excerpt

Common genetic variation at human 14q22.2 tagged by rs4444235 is significantly associated with colorectal cancer (CRC) risk. Re-sequencing was used to comprehensively annotate the 17kb region of strong linkage disequilibrium encompassing rs4444235. Through bioinformatic analyses using H3K4Me1, H3K4Me3, and DNase-I hypersensitivity chromatin signatures and evolutionary conservation we identified seven candidate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Bone Morphogenetic Protein 4

Share to Chromosomes, Human, Pair 14

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Source

Identifiers

PMID: 22158048
DOI: 10.1038/onc.2011.564

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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