Article
Targeted sequencing and functional interrogation identified novel variant at 12q14.2 associated with risk of ovarian cancer in Han Chinese women.
Carcinogenesis - 4 Sept 2025
Zhao Yanrui, Geng Wei, Liu Wei, Liu Lei, Teng Changcai, Chen Yuxin, Yang Dong, Chai Linqing, Wang Wei, Chu Xinlei, Huang Caiyun, Liu Ben, Chen Kexin, Zheng Hong, Li Lian
Abstract excerpt
Chromosome 12q14.2 has been reported as a potential risk locus for epithelial ovarian cancer (EOC) in genome-wide association study (GWAS). We performed targeted sequencing around the rs11175194 at chromosome 12q14.2 and identified five potential risk variants. The association between these five variants and EOC risk was evaluated in 893 EOC cases and 1292 controls. We identified that rs11175195 (P = 1.94 × 10-6,...
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