Article
Optimal antigens for HIV vaccines based on CD8+ T response, protein length, and sequence variability.
DNA and cell biology - 1 Sept 2002
Betts Michael R, Yusim Karina, Koup Richard A
Abstract excerpt
The identification of optimal antigens to include in an HIV vaccine designed to elicit a cellular immune response requires careful consideration of protein length, variability, and immunogenicity. Here, we have examined the relationship of these parameters in a cohort of HIV-infected subjects. We find that HIV Gag and Nef represent optimal antigens for the CD8+ T cell response, based on size, variability, and...
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