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Article

Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1.

BMC medical genetics - 8 Dec 2011

Sordillo Joanne E, Sharma Sunita, Poon Audrey, Lasky-Su Jessica, Belanger Kathleen, Milton Donald K, Bracken Michael B, Triche Elizabeth W, Leaderer Brian P, Gold Diane R, Litonjua Augusto A

Abstract excerpt

BACKGROUND: Polymorphisms in the endotoxin-mediated TLR4 pathway genes have been associated with asthma and atopy. We aimed to examine how genetic polymorphisms in innate immunity pathways interact with endotoxin to influence asthma risk in children. METHODS: In a previous analysis of 372 children from the Boston Home Allergens and the Connecticut Childhood Asthma studies, 7 SNPs in 6 genes (CARD15, TGFB1, LY96,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22151743
DOI: 10.1186/1471-2350-12-158
PMCID: PMC3252252

Genes

ACAA1
DEFB1
IFNG
IRAK2
STAT4
TGFB1
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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