Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[IDH1/2 mutations in gliomas].

Brain and nerve = Shinkei kenkyu no shinpo - 1 Dec 2011

Nobusawa Sumihito, Yokoo Hideaki

Abstract excerpt

The NADP+-dependent isocitrate dehydrogenases 1 and 2 (IDH1/2) catalyze the oxidative decarboxylation of isocitrate into α-ketoglutarate (α-KG). IDH1 and IDH2 mutations have been frequently found in some types of gliomas (low-grade diffuse gliomas WHO grade II, anaplastic gliomas WHO grade III, and secondary glioblastomas WHO grade IV), and have received significant attention because of their specificity to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to IDH1 gene
Share to IDH2 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioma

Share to Isocitrate Dehydrogenase

Share to Molecular Targeted Therapy

Share to Mutation

Share to Neoplasm Staging

Source

Identifiers

PMID: 22147457

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[IDH1/2 mutations in gliomas].PMID 22147457Read ↗

Isocitrate dehydrogenase mutations in gliomas.Semantic proximity Read ↗

New insights into glioma classification based on isocitrate dehydrogenase 1 and 2 gene status.Semantic proximity Read ↗

Isocitrate dehydrogenase 1 and 2 mutations in gliomas.Semantic proximity Read ↗

Isocitrate dehydrogenase mutations: a challenge to traditional views on the genesis and malignant progression of gliomas.Semantic proximity Read ↗

Biological Significance of Mutant Isocitrate Dehydrogenase 1 and 2 in Gliomagenesis.Semantic proximity Read ↗

Metabolism of glioma and IDH1/IDH2 mutations.Semantic proximity Read ↗

IDH1 and IDH2 mutations in gliomas.Semantic proximity Read ↗

Isocitrate dehydrogenase-1 mutations: a fundamentally new understanding of diffuse glioma?Semantic proximity Read ↗

IDH1/2 mutations target a key hallmark of cancer by deregulating cellular metabolism in glioma.Semantic proximity Read ↗

Isocitrate dehydrogenase status and molecular subclasses of glioma and glioblastomaSemantic proximity Read ↗

Isocitrate Dehydrogenase Mutations in Glioma: From Basic Discovery to Therapeutics DevelopmentSemantic proximity Read ↗

IDH1/2 mutation detection in gliomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.