The ATM Gene in Breast Cancer: Its Relevance in Clinical Practice.

doi:10.3390/genes12050727

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Article

The ATM Gene in Breast Cancer: Its Relevance in Clinical Practice.

Genes - 13 May 2021

Stucci Luigia Stefania, Internò Valeria, Tucci Marco, Perrone Martina, Mannavola Francesco, Palmirotta Raffaele, Porta Camillo

Abstract excerpt

Molecular alterations of the Ataxia-telangiectasia (AT) gene are frequently detected in breast cancer (BC), with an incidence ranging up to 40%. The mutated form, the Ataxia-telangiectasia mutated (ATM) gene, is involved in cell cycle control, apoptosis, oxidative stress, and telomere maintenance, and its role as a risk factor for cancer development is well established. Recent studies have confirmed that some...

Topics

Animals
Ataxia Telangiectasia Mutated Proteins
Biomarkers, Tumor
Breast Neoplasms
Drug Resistance, Neoplasm
Female
Humans
Mutation

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Identifiers

PMID: 34068084
DOI: 10.3390/genes12050727
PMCID: PMC8152746

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