Article
Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history.
Cancer - 1 Aug 2001
Teraoka S N, Malone K E, Doody D R, Suter N M, Ostrander E A, Daling J R, Concannon P
Abstract excerpt
BACKGROUND: An increased incidence of breast carcinoma has been reported among relatives of individuals who are affected with the rare recessive disorder, ataxia-telangiectasia (A-T), and who are heterozygous for mutations in the ataxia-telangiectasia mutated (ATM) gene. However, most studies of breast carcinoma cases from the general population have failed to find a higher incidence of ATM mutations in cases...
Topics
- Adult
- Age of Onset
- Ataxia Telangiectasia Mutated Proteins
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- Cell Cycle Proteins
- DNA-Binding Proteins
- Exons
- Family Health
- Female
- Gene Frequency
- Genetic Markers
- Humans