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Article

Severe reaction to radiotherapy provoked by hypomorphic germline mutations in ATM (ataxia-telangiectasia mutated gene).

Molecular genetics & genomic medicine - 1 Oct 2020

Asadollahi Reza, Britschgi Christian, Joset Pascal, Oneda Beatrice, Schindler Detlev, Meier Urs R, Rauch Anita

Abstract excerpt

BACKGROUND: A minority of breast cancer (BC) patients suffer from severe reaction to adjuvant radiotherapy (RT). Although deficient DNA double-strand break repair is considered the main basis for the reactions, pretreatment identification of high-risk patients has been challenging. METHODS: To retrospectively determine the etiology of severe local reaction to RT in a 39-year-old woman with BC, we performed...

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Share to alpha-Fetoproteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 32748564
DOI: 10.1002/mgg3.1409
PMCID: PMC7549565

Genes

ATM
AFP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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