Article
Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies.
Human molecular genetics - 15 Jul 2010
Zhang Lisheng, Connelly Jessica J, Peppel Karsten, Brian Leigh, Shah Svati H, Nelson Sarah, Crosslin David R, Wang Tianyuan, Allen Andrew, Kraus William E, Gregory Simon G, Hauser Elizabeth R, Freedman Neil J
Abstract excerpt
Aging is believed to be among the most important contributors to atherosclerosis, through mechanisms that remain largely obscure. Serum levels of tumor necrosis factor (TNF) rise with aging and have been correlated with the incidence of myocardial infarction. We therefore sought to determine whether genetic variation in the TNF receptor-1 gene (TNFR1) contributes to aging-related atherosclerosis in humans and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.