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Article

Birth, decay, and reconstruction of an ancient <i>TRIMCyp</i> gene fusion in primate genomes

14 Jan 2013

Abstract excerpt

TRIM5 is a host antiviral gene with an evolutionary history of genetic conflict with retroviruses. The TRIMCyp gene encodes a protein fusion of TRIM5 effector domains with the capsid-binding ability of a retrotransposed CyclophilinA (CypA), resulting in novel antiviral specificity against lentiviruses. Previous studies have identified two independent primate TRIMCyp fusions that evolved within the past 6 My....

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PMID: 23319649
DOI: 10.1073/pnas.1216542110

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