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Article

Interleukin-4 -590T/C polymorphism influences the susceptibility to nonsmall cell lung cancer.

DNA and cell biology - 1 May 2012

Li Xiaoyan, Shi Weiwei, Yu Guanzhen, Lin Li, Yang Bo, Li Jianxiong, Guo Wanfeng, Tang Chuanhao, Wang Hong, Gao Hongjun, Qin Haifeng, Liu Yi, Liu Xiaoqing

Abstract excerpt

Lung cancer is the leading cause of cancer mortality worldwide. Nonsmall cell lung cancer (NSCLC) accounts for most of these cases. Interleukin 4 (IL-4) is a typical pleiotropic T helper 2 cytokine and plays crucial roles in tumor immunology. IL-4 gene -590T/C polymorphism has been shown to be associated with different autoimmune diseases and cancers. The present study evaluated the correlation between this...

Topics

Adenocarcinoma
Asian People
Carcinoma, Large Cell
Carcinoma, Non-Small-Cell Lung
Carcinoma, Squamous Cell
Case-Control Studies
DNA
Female
Genetic Predisposition to Disease
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Interleukin-4

Lung

Lung Neoplasms

Male

Middle Aged

Polymerase Chain Reaction

Polymorphism, Genetic

Source

Identifiers

PMID: 22142023
DOI: 10.1089/dna.2011.1425

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22142023-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Interleukin-4 -590T/C polymorphism influences the susceptibility to nonsmall cell lung cancer.PMID 22142023Read ↗

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