Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between IL18-607C/A and -137G/C polymorphisms and susceptibility to non-small cell lung cancer in a Chinese population.

Genetics and molecular research : GMR - 19 Dec 2016

Gan W Y, Li H M, Zhang Y G, Li C M, Wang Y

Abstract excerpt

Lung cancer is one of the main causes of cancer-related mortality in males and females worldwide. A pleiotropic effect has been observed in the interleukin 18 gene (IL18); its effects include the activation of natural killer cell cytotoxicity and the promotion of the Th1 immune response through the alteration of the expression of interferon-γ and TNF-α in humans. IL18 is therefore involved in the elimination of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Asian People
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interferon-gamma

Share to Interleukin-18

Share to Lung Neoplasms

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 28002583
DOI: 10.4238/gmr15048822

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between IL18-607C/A and -137G/C polymorphisms and susceptibility to non-small cell lung cancer in a Chinese population.PMID 28002583Read ↗

Significant Contribution of Interleukin-18 Genotypes to Lung Cancer Risk in Taiwanese.Semantic proximity Read ↗

Interleukin-18 promoter polymorphism is associated with lung cancer: a case-control study.Semantic proximity Read ↗

Interleukin-18 gene promoter polymorphism and the risk of nasopharyngeal carcinoma in a Chinese population.Semantic proximity Read ↗

Review and pooled analysis of studies on -607(C/A) and -137(G/C) polymorphisms in IL-18 and cancer risk.Semantic proximity Read ↗

The -137G>C polymorphism in interleukin-18 promoter region and cancer risk: evidence from a meta-analysis of 21 studies.Semantic proximity Read ↗

Interleukin 17A genetic variations and susceptibility to non-small cell lung cancer.Semantic proximity Read ↗

Association of interleukin-18 gene promoter -607 C>A and -137G>C polymorphisms with cancer risk: a meta-analysis of 26 studies.Semantic proximity Read ↗

Genetic polymorphisms of IL-10, IL-18 and IL12B are associated with risk of non-small cell lung cancer in a Chinese Han population.Semantic proximity Read ↗

Association analysis of interleukin-18 gene promoter region polymorphisms and susceptibility to sporadic breast cancer in Chinese Han women.Semantic proximity Read ↗

Significant association of the cytokine variants with head and neck cancer risk: evidence from meta-analysis.Semantic proximity Read ↗

The -137G/C single nucleotide polymorphism in IL-18 gene promoter contributes to tuberculosis susceptibility in Chinese Han population.Semantic proximity Read ↗

Potential Impacts of Interleukin-17A Promoter Polymorphisms on the EGFR Mutation Status and Progression of Non-Small Cell Lung Cancer in Taiwan.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.