Article
Significant impact of IL-6 -174G/C but inverse relation with -634 C/G polymorphism in patients with non-small cell lung cancer in Kashmiri population.
Immunological investigations - 1 Jan 2015
Bhat Imtiyaz A, Qasim Iqbal, Masoodi Khalid Z, Paul Shabeer A, Bhat Bashir A, Rasool Roohi, Aziz S A, Shah Zafar A
Abstract excerpt
To study the possible role of proinflammatory interleukin 6 -174 G>C (rs 1800795) and -634 C>G (rs 1800796) polymorphism in the pathogenesis of non-small cell lung cancer (NSCLC). A total of 190 NSCLC patients and 200 healthy controls were evaluated for polymorphic analysis of -174 G/C and -634 C/G by PCR-RFLP followed by DNA sequencing. A significant association was observed in the genotypic and allelic...
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