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Article

CTLA-4 +49A>G polymorphism is associated with advanced non-small cell lung cancer prognosis.

Respiration; international review of thoracic diseases - 1 Jan 2011

Song Bao, Liu Yanbing, Liu Jie, Song Xianrang, Wang Zhehai, Wang Mingyu, Zhu Yufang, Han Jinxiang

Abstract excerpt

BACKGROUND: Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a potent immunoregulatory molecule that suppresses antitumor response by downregulating T cell activation. The most studied +49A>G polymorphism of the CTLA-4 gene has been associated with several autoimmune diseases. However, little is known about the association between this functional polymorphism of CTLA-4 and cancer prognosis. OBJECTIVE: To investigate...

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Source

Identifiers

PMID: 21832820
DOI: 10.1159/000329345

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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