The co-existence of the IL-18+183 A/G and MMP-9 -1562 C/T polymorphisms is associated with clinical events in coronary artery disease patients.

doi:10.1371/journal.pone.0074498

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Article

The co-existence of the IL-18+183 A/G and MMP-9 -1562 C/T polymorphisms is associated with clinical events in coronary artery disease patients.

PloS one - 1 Jan 2013

Opstad Trine B, Pettersen Alf Å, Arnesen Harald, Seljeflot Ingebjørg

Abstract excerpt

OBJECTIVE: Interleukin (IL)-18 has been associated with severity of atherosclerosis and discussed to predict cardiovascular (CV) events. We have previously shown that the IL-18+183 G-allele significantly reduces IL-18 levels. This study was aimed to investigate the prognostic significance of the IL-18+183 A/G polymorphism (rs5744292), single and in coexistence with the matrix metalloproteinase (MMP)-9 -1562 C/T...

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PMID: 24040261
DOI: 10.1371/journal.pone.0074498
PMCID: PMC3764212

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