Article
Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency.
Scientific reports - 14 Oct 2016
Kulminski Alexander M, Loika Yury, Culminskaya Irina, Arbeev Konstantin G, Ukraintseva Svetlana V, Stallard Eric, Yashin Anatoliy I
Abstract excerpt
Common strategy of genome-wide association studies (GWAS) relying on large samples faces difficulties, which raise concerns that GWAS have exhausted their potential, particularly for complex traits. Here, we examine the efficiency of the traditional sample-size-centered strategy in GWAS of these traits, and its potential for improvement. The paper focuses on the results of the four largest GWAS meta-analyses of...
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