Article
From single-SNP to wide-locus: genome-wide association studies identifying functionally related genes and intragenic regions in small sample studies.
Pharmacogenomics - 1 Mar 2013
Wittkowski Knut M, Sonakya Vikas, Song Tingting, Seybold Martin P, Keddache Mehdi, Durner Martina
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) have had limited success when applied to complex diseases. Analyzing SNPs individually requires several large studies to integrate the often divergent results. In the presence of epistasis, multivariate approaches based on the linear model (including stepwise logistic regression) often have low sensitivity and generate an abundance of artifacts. METHODS: Recent...
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