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Production and cryopreservation of definitive endoderm from human pluripotent stem cells under defined and scalable culture conditions

12 Feb 2021

Abstract excerpt

The endodermal germ layer gives rise to respiratory epithelium, hepatocytes, pancreatic cells and intestinal lineages, among other cell types. These lineages can be differentiated from human pluripotent stem cells (hPSCs) via a common definitive endoderm (DE) intermediate that is characterized by the co-expression of the cell surface markers CXCR4, c-KIT and EPCAM and the transcription factors SOX17 and FOXA2....

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PMID: 33580232
DOI: 10.1038/s41596-020-00470-5

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