Article
In vitro expansion of human cardiac progenitor cells: exploring 'omics tools for characterization of cell-based allogeneic products.
Translational research : the journal of laboratory and clinical medicine - 1 May 2016
Gomes-Alves P, Serra M, Brito C, Ricardo C P, Cunha R, Sousa M F, Sanchez B, Bernad A, Carrondo M J T, Rodriguez-Borlado L, Alves P M
Abstract excerpt
Human cardiac stem/progenitor cells (hCPCs) have been shown to be capable to regenerate contractile myocardium. However, because of their relative low abundance in the heart, in vitro expansion of hCPC is mandatory to achieve necessary quantities for allogeneic or autologous cardiac regeneration therapy applications (10(6)-10(9) cells/patient). Up to now, cell number requirements of ongoing phase I/IIa trials...
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