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Article

Double-strand break damage and associated DNA repair genes predispose smokers to gene methylation.

Cancer research - 15 Apr 2008

Leng Shuguang, Stidley Christine A, Willink Randy, Bernauer Amanda, Do Kieu, Picchi Maria A, Sheng Xin, Frasco Melissa A, Van Den Berg David, Gilliland Frank D, Zima Christopher, Crowell Richard E, Belinsky Steven A

Abstract excerpt

Gene promoter hypermethylation in sputum is a promising biomarker for predicting lung cancer. Identifying factors that predispose smokers to methylation of multiple gene promoters in the lung could affect strategies for early detection and chemoprevention. This study evaluated the hypothesis that double-strand break (DSB) repair capacity and sequence variation in genes in this pathway are associated with a high...

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Share to Promoter Regions, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18413776
DOI: 10.1158/0008-5472.CAN-07-6344
PMCID: PMC2483467

Genes

CHEK2
NBN
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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