15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers.

doi:10.1093/jnci/djv035

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Article

15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers.

Journal of the National Cancer Institute - 23 Feb 2015

Leng Shuguang, Liu Yushi, Weissfeld Joel L, Thomas Cynthia L, Han Younghun, Picchi Maria A, Edlund Christopher K, Willink Randall P, Gaither Davis Autumn L, Do Kieu C, Nukui Tomoko, Zhang Xiequn, Burki Elizabeth A, Van Den Berg David, Romkes Marjorie, Gauderman W James, Crowell Richard E, Tesfaigzi Yohannes, Stidley Christine A, Amos Christopher I, Siegfried Jill M, Gilliland Frank D, Belinsky Steven A

Abstract excerpt

BACKGROUND: Lung cancer is the leading cause of cancer-related mortality worldwide. Detection of promoter hypermethylation of tumor suppressor genes in exfoliated cells from the lung provides an assessment of field cancerization that in turn predicts lung cancer. The identification of genetic determinants for this validated cancer biomarker should provide novel insights into mechanisms underlying epigenetic...

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PMID: 25713168
DOI: 10.1093/jnci/djv035
PMCID: PMC4555640

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GABRB3

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