Article
DNA repair excision nuclease attacks undamaged DNA. A potential source of spontaneous mutations.
The Journal of biological chemistry - 6 Jul 2001
Branum M E, Reardon J T, Sancar A
Abstract excerpt
Nucleotide excision repair is a general repair system that eliminates many dissimilar lesions from DNA. In an effort to understand substrate determinants of this repair system, we tested DNAs with minor backbone modifications using the ultrasensitive excision assay. We found that a phosphorothioate and a methylphosphonate were excised with low efficiency. Surprisingly, we also found that fragments of 23-28...
Topics
- Base Sequence
- DNA Damage
- DNA Repair
- DNA, Bacterial
- Deoxyribonucleases
- Escherichia coli
- Guanine
- Humans
- Models, Chemical
- Molecular Sequence Data
- Mutation
- Organophosphorus Compounds