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Article

Modified bases enable high-efficiency oligonucleotide-mediated allelic replacement via mismatch repair evasion.

Nucleic acids research - 1 Sept 2011

Wang Harris H, Xu George, Vonner Ashley J, Church George

Abstract excerpt

Genome engineering using single-stranded oligonucleotides is an efficient method for generating small chromosomal and episomal modifications in a variety of host organisms. The efficiency of this allelic replacement strategy is highly dependent on avoidance of the endogenous mismatch repair (MMR) machinery. However, global MMR inactivation generally results in significant accumulation of undesired background...

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Identifiers

PMID: 21609953
DOI: 10.1093/nar/gkr183
PMCID: PMC3167615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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