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Article

E17A mutation in HIV-1 Vpr confers resistance to didanosine in association with thymidine analog mutations.

Antiviral research - 1 Jan 2012

Fourati Slim, Malet Isabelle, Guenzel Carolin A, Soulie Cathia, Maidou-Peindara Priscilla, Morand-Joubert Laurence, Wirden Marc, Sayon Sophie, Peytavin Gilles, Simon Anne, Katlama Christine, Benichou Serge, Calvez Vincent, Marcelin Anne-Geneviève

Abstract excerpt

BACKGROUND: HIV-1 accessory Vpr protein is involved in the reverse transcription process and has been shown to modulate the virus mutation rate. This process may play a role in the kinetics of appearance of drug resistance mutations under antiretroviral treatment. METHODS: Vpr sequences were analyzed from plasma viruses derived from 97 HIV-1-infected individuals failing antiretroviral treatment and 63...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to vpr Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 22138483
DOI: 10.1016/j.antiviral.2011.11.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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