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Article

Revertant mutation V48G alters conformational dynamics of highly drug resistant HIV protease PRS17.

Journal of molecular graphics & modelling - 1 Nov 2021

Burnaman Shelley H, Kneller Daniel W, Wang Yuan-Fang, Kovalevsky Andrey, Weber Irene T

Abstract excerpt

Drug resistance is a serious problem for controlling the HIV/AIDS pandemic. Current antiviral drugs show several orders of magnitude worse inhibition of highly resistant clinical variant PRS17 of HIV-1 protease compared with wild-type protease. We have analyzed the effects of a common resistance mutation G48V in the flexible flaps of the protease by assessing the revertant PRS17V48G for changes in enzyme...

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Source

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Identifiers

PMID: 34419931
DOI: 10.1016/j.jmgm.2021.108005
PMCID: PMC8435028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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