Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of accessory mutations associated with high-level resistance in HIV-1 reverse transcriptase.

AIDS (London, England) - 19 Feb 2007

Cane Patricia A, Green Hannah, Fearnhill Esther, Dunn David

Abstract excerpt

OBJECTIVE: To identify accessory mutations associated with high levels of resistance to reverse transcriptase inhibitors (RTI). DESIGN: HIV pol sequences from routine resistance tests from over 3000 patients who were treatment experienced and infected with subtype B HIV-1 were analysed. Changes relative to the wild-type amino acid for codons 1-400 of reverse transcriptase were determined in two series: (i)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Amino Acids
Share to Anti-HIV Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Databases, Factual

Share to Drug Resistance, Viral

Share to HIV Reverse Transcriptase

Share to Reverse Transcriptase Inhibitors

Source

Identifiers

PMID: 17301563
DOI: 10.1097/QAD.0b013e3280129964

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of accessory mutations associated with high-level resistance in HIV-1 reverse transcriptase.PMID 17301563Read ↗

Subtype-specific differences in the development of accessory mutations associated with high-level resistance to HIV-1 nucleoside reverse transcriptase inhibitors.Semantic proximity Read ↗

Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors.Semantic proximity Read ↗

UPDATE ON DRUG RESISTANCE MUTATIONS IN HIV-1Semantic proximity Read ↗

Identification of alternative amino acid substitutions in drug-resistant variants of the HIV-1 reverse transcriptase.Semantic proximity Read ↗

Primary HIV-1 drug resistance in the C-terminal domains of viral reverse transcriptase among drug-naïve patients from Southern Brazil.Semantic proximity Read ↗

N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance.Semantic proximity Read ↗

HIV-1 reverse transcriptase connection domain mutations: dynamics of emergence and implications for success of combination antiretroviral therapy.Semantic proximity Read ↗

Accessory mutations maintain stability in drug-resistant HIV-1 protease.Semantic proximity Read ↗

Combinations of mutations in the connection domain of human immunodeficiency virus type 1 reverse transcriptase: assessing the impact on nucleoside and nonnucleoside reverse transcriptase inhibitor resistance.Semantic proximity Read ↗

Accumulation of Multiple Mutations In Vivo Confers Cross-Resistance to New and Existing Integrase InhibitorsSemantic proximity Read ↗

Early selection of resistance-associated mutations in HIV-1 RT C-terminal domains across different subtypes: role of the genetic barrier to resistance.Semantic proximity Read ↗

Mutations in the thumb-connection and RNase H domain of HIV type-1 reverse transcriptase of antiretroviral treatment-experienced patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.