Article
The reverse transcriptase 67N 70R 215Y genotype is the predominant TAM pathway associated with virologic failure among HIV type 1C-infected adults treated with ZDV/ddI-containing HAART in southern Africa.
AIDS research and human retroviruses - 1 Jul 2007
Novitsky Vlad, Wester C William, DeGruttola Victor, Bussmann Hermann, Gaseitsiwe Simani, Thomas Ann, Moyo Sikhulile, Musonda Rosemary, Van Widenfelt Erik, Marlink Richard G, Essex M
Abstract excerpt
HIV-1C has become the dominant HIV-1 subtype in the global AIDS epidemic. Historically, the evolution of drug-resistant mutations was characterized primarily among antiretroviral (ARV)-treated HIV-1B infections. Whereas the non-B viruses are susceptible to the currently used ARVs, some differences between HIV-1 subtypes in response to ARV regimens have been reported. We analyzed the profile of ARV-associated...
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