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Article

Combined genetic inactivation of β2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma.

Cancer cell - 13 Dec 2011

Challa-Malladi Madhavi, Lieu Yen K, Califano Olivia, Holmes Antony B, Bhagat Govind, Murty Vundavalli V, Dominguez-Sola David, Pasqualucci Laura, Dalla-Favera Riccardo

Abstract excerpt

We report that diffuse large B cell lymphoma (DLBCL) commonly fails to express cell-surface molecules necessary for the recognition of tumor cells by immune-effector cells. In 29% of cases, mutations and deletions inactivate the β2-Microglobulin gene, thus preventing the cell-surface expression of the HLA class-I (HLA-I) complex that is necessary for recognition by CD8(+) cytotoxic T cells. In 21% of cases,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Copy Number Variations

Share to Histocompatibility Antigens Class I

Share to Killer Cells, Natural

Share to Lymphoma, Large B-Cell, Diffuse

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Source

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Identifiers

PMID: 22137796
DOI: 10.1016/j.ccr.2011.11.006
PMCID: PMC3660995

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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