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Article

Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphoma

28 May 2021

Abstract excerpt

Significance Fifty percent of diffuse large B cell lymphoma (DLBCL) evade immune-surveillance via somatic genetic lesions abrogating the expression of the class I major histocompatibility complex (MHC-I) complex on the cell surface, thus preventing the presentation of tumor neoantigens to the immune system. The results herein significantly extend these findings by showing that an additional 40% of DLBCL cases,...

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Identifiers

PMID: 34050029
DOI: 10.1073/pnas.2104504118

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