Article
X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells.
The Journal of experimental medicine - 7 Aug 2000
Parolini S, Bottino C, Falco M, Augugliaro R, Giliani S, Franceschini R, Ochs H D, Wolf H, Bonnefoy J Y, Biassoni R, Moretta L, Notarangelo L D, Moretta A
Abstract excerpt
2B4 is a surface molecule involved in activation of the natural killer (NK) cell-mediated cytotoxicity. It binds a protein termed Src homology 2 domain-containing protein (SH2D1A) or signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), which in turn has been proposed to function as a regulator of the 2B4-associated signal transduction pathway. In this study, we analyzed patients with X-linked...
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