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Article

Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.

Leukemia & lymphoma - 1 Jan 2016

Higashi Morihiro, Tokuhira Michihide, Fujino Satoshi, Yamashita Takahisa, Abe Keiko, Arai Eiichi, Kizaki Masahiro, Tamaru Jun-ichi

Abstract excerpt

The interaction between tumor cells and the tumor microenvironment is essential in the development and progression of diffuse large B-cell lymphoma (DLBCL). Loss of human leukocyte antigen DR (HLA-DR) in DLBCL is a robust adverse prognostic marker. We evaluated the immunohitochemical expression of HLA-DR in lymphoma and the biologic implications of the loss of HLA-DR. The loss of HLA-DR correlated with clinical...

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Identifiers

PMID: 25860238
DOI: 10.3109/10428194.2015.1038708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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