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Article

CD58 Alterations Govern Antitumor Immune Responses by Inducing PDL1 and IDO in Diffuse Large B-Cell Lymphoma.

Cancer research - 2 Jul 2024

Xu Xiyue, Zhang Yidan, Lu Yaxiao, Zhang Xiaoyan, Zhao Cuicui, Wang Jiesong, Guan Qingpei, Feng Yingfang, Gao Meng, Yu Jingwei, Song Zheng, Liu Xia, Golchehre Zahra, Li Lanfang, Ren Weicheng, Pan-Hammarström Qiang, Zhang Huilai, Wang Xianhuo

Abstract excerpt

Recurrent abnormalities in immune surveillance-related genes affect the progression of diffuse large B-cell lymphoma (DLBCL) and modulate the response to therapeutic interventions. CD58 interacts with the CD2 receptor on T cells and NK cells and is recurrently mutated and deleted in DLBCL, suggesting that it may play a role in regulating antitumor immunity. In this study, we comprehensively analyzed the genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to STAT1 gene

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Share to Lymphoma, Large B-Cell, Diffuse

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Source

Identifiers

PMID: 38635903
DOI: 10.1158/0008-5472.CAN-23-2874

Genes

CD58
CD2
CD22
LYN
JAK2
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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